By Ivana Pantelic
The on-going ‘green’ pattern within the own care coupled with worldwide environmental issues, position natural-origin, biodegradable and skin-friendly surfactants reminiscent of alkyl polyglucosides (APGs) in excessive call for. After profitable use in cosmetics, enough information has been got to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides provides a entire compendium which courses a researcher from the APG-related preformulation levels to formula processing, together with the research of varied APG-stabilized platforms epidermis functionality. This ebook introduces quite a few APG representatives, their merits on the subject of definite traditional surfactants, physicochemical and interfacial houses, attainable interplay with commonplace components and various characterization recommendations critical for the overview of colloidal platforms. the 1st bankruptcy introduces alkyl polyglucosides, by way of chapters on their houses, behaviour, an summary of the patent security mechanisms and guidance for filing patent purposes. ultimately, a end surveys overseas patent purposes related to APGs.
- introduces the sector of alkyl polyglucoside emulsifiers, directory all of the modern and newly synthesized APG emulsifiers
- provides specific info on a variety of elements of APG-based constructions
- reveals capability of APG-stabilized automobiles as potential supply structures utilizing numerous version medicines and beauty actives
- includes an updated evaluation of study carried out within the box of APGs, facilitating destiny preformulation and formula experiences for researchers
- offers a concise and useful compendium of characterization strategies
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Additional info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
1997). 3 Physicochemical properties of APGs APGs show peculiar physicochemical behaviour. They are generally stable at high pH and sensitive to low pH, at which they hydrolyse to sugar and fatty alcohol moieties. g. Polysorbates). This makes the physicochemical behaviour of APGs in oil–water systems distinctly different from that of conventional non-ionics. , 2010). 1 Critical micelle concentration and micelle shape When discussing surfactant behaviour in solution, the keystone is research into their critical micelle concentration (CMC).
In: Rieger M, Rhein L, eds. Surfactants in cosmetics. New York: Marcel Dekker, 1997. Kluge K, Sottmann T, Stubenrauch C, Strey R. Temperature-insensitive microemulsions formulated from octyl monoglucoside and alcohols: potential candidates for applications. Tenside Surf Deterg 2001; 38: 30–40. Kovacevic A, Savic S, Vuleta G, Müller RH, Keck CM. Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure. Int J Pharm 2011; 406 (1–2): 163–72.
1 Surfactants CMC values of C8–C14 APGs Critical micelle concentration (CMC) (mol/l) γCMC ppm C8APG 1,712 × 10−3 500 29 C9APG 1,225 × 10 −3 375 33 7,812 × 10 −4 250 31 C12APG 2,973 × 10 −4 100 32 C14APG 2,659 × 10−5 25 30 C10APG point, the surface tension in the surfactant solution is constant. The surface tension decreases steeply with the surfactant concentration increase up to one point, and then becomes constant. That break in the plot or point of inflection is taken as the CMC. 1. The CMC value decreases as the number of C-atoms in the lipophilic (hydrophobic) chain increases; thus, the octyl polyglucoside has the highest CMC value, whereas tetradecyl Alkyl Polyglucoside has the lowest.